Spiroindolones

Details Spiroindolones Spiroindolones

1979-08-06

1980-10-07

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260325R, 424246, 424250, 424263, 424267, 424274, A61K 31405, A61K 3154, C07D20996, C07D49310

Patent

active

042268605

ABSTRACT:
Herein is disclosed spiroindolone derivatives of the formula ##STR1## in which R.sup.1 is lower alkyl or carboxy(lower)alkyl, R.sup.2 is lower alkyl, R.sup.3 is lower alkyl or phenyl(lower)alkyl, and X is oxygen or CH.sub.2, or a therapeutically acceptable base addition salt thereof when R.sup.1 is carboxy(lower)alkyl, a process for their preparation, methods of using the derivatives and pharmaceutical compositions of the derivatives. The derivatives are useful for treating hypertension in a mammal.

REFERENCES:
patent: 3308134 (1967-03-01), Plostnieks
patent: 3723459 (1973-03-01), Paragamian
Jonsson et al., Acta Chem. Scand., B, vol. 28, pp. 225-232, (1974).
Patrick et al., J. Am. Chem. Soc., vol. 72, pp. 633-634, (1950).
Witkop et al., J. Am. Chem. Soc., vol. 75, pp. 2572-2576, (1953).
Sundberg, The Chemistry of Indoles, (Academic Press, New York, 1970), pp. 296-303.

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