Method for preparing crystalline hydrate of oral celphalosporin

Details Method for preparing crystalline hydrate of oral celphalosporin Method for preparing crystalline hydrate of oral celphalosporin

1988-11-21

1990-06-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50124, A61K 31545

Patent

active

049334433

ABSTRACT:
An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule and sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

REFERENCES:
patent: 4820833 (1989-04-01), Crisp et al.

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