Benzoic acid derivatives and use thereof

Details Benzoic acid derivatives and use thereof Benzoic acid derivatives and use thereof

1988-03-30

1990-06-12

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514162, 514163, A61K 3160, A61K 3161, A61K 31615

Patent

active

049333305

ABSTRACT:
A pharmaceutical composition for use in the treatment of psoriasis comprises 4-aminosalicylic acid (4-ASA) or 5-aminosalicylic acid (5-ASA) or a functional derivative thereof, said pharmaceutical composition being in a form suitable for topical administration. Furthermore, 4- or 5-ASA or a functional derivative thereof are used for the manufacture of pharmaceutical compositions for treating psoriasis, atopic dermatitis, allergic dermatitis, contact dermatitis, seborrhoic dermatitis, or acne diseases. The derivatives have the formulae: ##STR1## where W is COOX, wherein X is H, Li, Na, K, Mg.sub.0.5, Ca.sub.0.5, Zn.sub.0.5, Al.sub.0.33, Fe(II).sub.0.5, Fe(III).sub.0.33, NH.sub.4, NH.sub.3 R.sup.1, NH.sub.2 R.sup.1.sub.2, NHR.sup.1.sub.3, NR.sup.1.sub.4, or R.sup.1, where R.sup.1 is substituted or unsubstituted C.sub.1-6 -alkyl, aryl-C.sub.1-4 -alkyl, or heteroaryl-C.sub.1-4 -alkyl; or COX, where X is NR.sup.1 R.sup.1', where R.sup.1' has the same meaning as R.sup.1 defined above and R.sup.1 and R.sup.1' may be identical or different; Y is H or R.sup.1 CO, where R.sup.1 is defined as above; Z.sup.1 and Z.sup.2, which may be identical or non-identical are H, R.sup.1 or R.sup.1 CO, where R.sup.1 is defined as above, or Z.sup.1 and Z.sup.2 represent R.sup.2, where R.sup.2 is substituted or unsubstituted C.sub.1-6 -alkylidene or aryl-C.sub.1-6 -alkylidene, or heteroaryl-C.sub.1-6 -alkylidene, or Z.sup.1, Z.sup.2 together with the nitrogen atom to which they are attached may represent a 3 to 7 membered saturated or unsaturated heterocyclic ring, or may represent a group of the formula --N.dbd.N--R.sup.3 where R.sup.3 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl.

REFERENCES:
patent: 4036951 (1977-07-01), Halpern et al.
patent: 4056624 (1977-11-01), Lassman et al.
patent: 4483854 (1984-11-01), Diamond
patent: 4767750 (1988-08-01), Jacquet et al.
Med. Actual, vol. 20, No. 10, pp. 472-474, (1984).

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