Plastin isoforms and their use

Details Plastin isoforms and their use Plastin isoforms and their use

1990-03-16

1991-03-26

Schain, Howard E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

530387, 530324, 530350, 43524027, 424 858, 536 27, A61K 39395, G01N 33574, G01N 3353

Patent

active

050028707

ABSTRACT:
A method and reagents are provided for determining whether a human cell is a hemopoietic cell and whether a human tissue cell is in a neoplastic state. Human cells which express only leukocyte-plastin (1-plastin) are hemopoietic cells and human cells which express both 1-plastin and tissue-plastin (t-plastin) are neoplastic. The method can be performed using isoform-specific plastin nucleotide probes or isoform-specific antiplastin antibodies.

REFERENCES:
Varma, Exp. Cell Res. (1987), 173: 163-173.
Leavitt, et al., Cell 28:259-268 (1982).
Goldstein, et al, Cancer Res., 45:3256-3261 (1985).
Leavitt, et al, Mol. Cell. Biol., 6:2721-2726 (1986).
Leavitt, et al, J. Biol. Chem., 255:1650-1661 (1980).
Leavitt, et al, Carcinogenesis (London), 3:61-70 (1982).
Goldstein, et al, Cancer Res., 45:5643-5647 (1985).
Varma, et al, Exp. Cell. Res., 173:163-173 (1987).
Goldman, et al, Clin. Chem., 28:1021-1025 (1982).
Goldman, et al, Am. J. Hum. Genet., 35:827-837 (1983).
Goldman, et al, Am. J. Hum. Genet., 37:898-911 (1985).
Kondo, et al, Am. J. Hum. Genet., 37:1106-1111 (1985).

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