Preparation of thieno-imidazole derivatives

Details Preparation of thieno-imidazole derivatives Preparation of thieno-imidazole derivatives

1985-03-14

1987-06-02

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548147, 548154, C07D49504

Patent

active

046705643

ABSTRACT:
A process for the preparation of a thieno-imidazole derivative, particularly descarboxybiotin, a useful intermediate for the preparation of d-biotin, which comprises reacting a thio-substituted intermediate, for example descarboxythiobiotin, with an epoxy compound in an alkanol solvent; and a process for the preparation of said intermediate by reacting a substituted imidazothiazole alcohol with anhydrous hydrogen fluoride.

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patent: 4029647 (1977-06-01), Confalone et al.
patent: 4124595 (1978-11-01), Confalone et al.
patent: 4486516 (1984-08-01), Volkmann
Chemical Abstracts, 98: 199537g (1983) [Penaloza, M., et al., Rev. Soc. Quim. Mex. 1982, 26(5), 245-7].
Chemical Abstracts, 92: 180975c (1980) [UK 1,551,078, 8/22/79].
Culvenor, C., et al., J. Chem. Soc., 1946, p. 1050.

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