Arachidonic acid analogs

Details Arachidonic acid analogs Arachidonic acid analogs

1986-05-21

1987-06-02

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514544, 514568, 558416, 560 18, 560 64, 560 65, 560104, 562432, 562473, 562474, 562495, C07C 6992, C07C14940, A61K 3119, A61K 31235

Patent

active

046704655

ABSTRACT:
Long chain unsaturated hydrocarbon derivatives, having from 13 to 21 carbon atoms, which are substituted at the 1-position by a phenoxy, phenylthio or a phenyl that bear a carboxylic acid group at the ortho, meta or para positions, and up to 4 carbon-carbon triple bonds, methods of preparing them, and pharmaceutical preparations containing them. These compounds are useful as lipoxygenase inhibitors, and therefore as antiinflammatory agents.

REFERENCES:
patent: 3705187 (1972-12-01), Chodnekar
patent: 3712913 (1973-01-01), Chodnekar
patent: 3829442 (1974-08-01), Schelling
patent: 3832385 (1974-08-01), Siddall
patent: 3833642 (1974-09-01), Chodnekar
patent: 4138579 (1979-02-01), Chodnekar
patent: 4482734 (1984-11-01), Yamatsu

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