Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-03-07
1985-02-19
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546283, 546339, 546340, 546341, A61K 3144, C07D21348, C07D21351
Patent
active
045005354
ABSTRACT:
A series of 4-(2-carboxymethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable salts, are disclosed as having immunoregulatory activity. Preferred compounds include 4-(2-carboxymethylthiomethyl)pyridine [alternatively named 2-(4-picolylthio)acetic acid] and (C.sub.1 -C.sub.4)alkyl esters thereof, and 4-(1-formylmethylthiomethyl)-pyridine [alternatively named 2-(4-picolylthio)acetaldehyde] and bis(C.sub.1 -C.sub.4)alkyl or cyclic acetals thereof. These acids, esters, aldehydes and acetals also have utility as intermediates in the synthesis of the corresponding 4-(2-hydroxyethylthiomethyl)pyridines.
REFERENCES:
Burger, Medicinal Chemistry, Third Edition, Part I, p. 788, Wiley-Interscience Pub.
Burger, Medicinal Chemistry, Third Edition, Part 2, p. 965, Wiley-Interscience Pub.
T. Di Perri et al., European Journal of Rheumatology and Inflammation, vol. 1, pp. 155-164, (1978).
R. F. van Ginckel et al., Eur. J. Immunol., vol. 6, pp. 305-307, (1976).
Harbert Charles A.
Lombardino Joseph G.
Pfizer Inc.
Rotman Alan L.
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