Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Anti-idiotypic
Patent
1985-05-28
1987-06-02
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Anti-idiotypic
A61K 3324
Patent
active
046702628
ABSTRACT:
The present invention relates to the preparation of sterile and stable freeze-dried forms of Cisplatinum containing from 10 to 50 mg of active ingredient, which can be obtained on an industrial scale and which have particular characteristics of facility and rapidity of dissolution which permit them to be used in a more advantageous and rational manner in antitumor chemotherapy, as compared with the freeze-dried forms of Cisplatinum presently on the market.
These particular characteristics are achieved as the result of employing special ingredients in respect of formulation (concentration of the solution to be freeze-dried, introduction of alcohols, adjustment of the pH of the solution to an appropriate value), and as the result of using a manufacturing technique having as its final stage the freeze-drying of Cisplatinum in a water-alcoholic medium.
The manufacturing method, and in particular the freeze-drying process, have shown themselves to be economically advantageous, and have made it possible to overcome the very considerable problems connected with the freeze-drying of Cisplatinum in aqueous medium (breakage of containers, very low yields), as well as to obtain preparations perfectly adapted to be used therapeutically by intravenous administration.
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See-Lasley et al., "Manual of Oncology Therapeutics", The C. V. Masby Company, pp. 189-190 (1981).
Battelli Gaetano
Oldani Diego
Rigamonti Alessandro
Farmitalia Carlo Erba S.p.A.
Goldberg Jerome D.
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