Novel 4H-1,2,4-triazole derivatives

Details Novel 4H-1,2,4-triazole derivatives Novel 4H-1,2,4-triazole derivatives

1986-08-14

1988-02-23

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548262, C07D24908, A61K 3141

Patent

active

047270845

ABSTRACT:
Compounds selected from the group consisting of 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene ring, R.sub.1, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CH.sub.3, --NO.sub.2, --NH.sub.2 and NH--AlK and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2, --NH--AlK and ##STR3## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting of ethyl, --CH.sub.2 --COOH and CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts, with the proviso that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all hydrogen having a remarkable analgesic activity and a novel method for their preparation.

REFERENCES:
patent: 4119635 (1978-10-01), Omodei-Sale et al.
Kendall et al., C.A. 51, 16162-16163 (1951) Cyanine Dyes.
Reimlinger et al., C.A., vol. 74:87898y (1971), Cyclo Condensation of Open Chain Amidrazones.
Spassor et al., Ber. Deut. Chem., vol. 99, No. 12, pp. 3728-3733 (1966).
Huisgen et al., Chemesche Buichte, vol. 93, No. 12 (1960), pp. 2885-2891.

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