Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1987-03-23
1988-08-16
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544385, A61K 3150, C07D40308
Patent
active
047646144
ABSTRACT:
The compound (S)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione) is prepared by treating propylenediamine tetraacetic tetraamide in a dipolar aprotic solvent with an alkali metal derivative of dimethyl sulfoxide to form a dialkali metal salt of (S)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione); and neutralizing the dialkali metal salt.
REFERENCES:
patent: 3941790 (1976-03-01), Creighton
patent: 4275063 (1981-06-01), Creighton
Journal of Medicinal Chemistry, vol. 20, No. 5, pp. 630-635, (1977).
Journal of Medicinal Chemistry, vol. 21, No. 12, pp. 1194-1197 (1978).
Daus Donald G.
Monsanto Company
Noel Mark W.
Shearin Frank D.
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