Process for the purification of lincomycin

Details Process for the purification of lincomycin Process for the purification of lincomycin

1981-01-26

1982-03-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1516

Patent

active

043179037

ABSTRACT:
A recovery process, using a reverse-phase high performance preparative liquid chromatography (hpplc) which gives a highly pure preparation of the useful antibiotic lincomycin hydrochloride. While giving a highly pure preparation of lincomycin hydrochloride, wherein less than about 0.5% of lincomycin B hydrochloride is present, the process also yields analytically pure lincomycin B hydrochloride which can be used as a laboratory standard.

REFERENCES:
patent: 3544552 (1970-12-01), Argoudelis et al.
patent: 3907774 (1975-09-01), Argoudelis et al.
Brown, "Jour. Pharm. Sci.," vol. 67, No. 9, Sep. 1978, pp. 1254-1257.

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