Chemical process for preparing .DELTA.9(11) dehydrosteroids

Details Chemical process for preparing .DELTA.9(11) dehydrosteroids Chemical process for preparing .DELTA.9(11) dehydrosteroids

1976-05-21

1977-12-20

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 500, C07J 300

Patent

active

040641481

ABSTRACT:
The Specification describes a synthetic route for the preparation of a 9,11-dehydro-3-oxygenated 17.alpha.-hydroxy-20-ketopregnane which comprises the steps (i) electrophilically fluorinating a saturated 9,11-unsubstituted 3-oxygenated-17.alpha.-(esterified hydroxy)-20-ketopregnane, (ii) dehydrofluorinating the resulting 9.alpha.-fluorosteroid, if desired after transformations elsewhere in the molecule have been effected, and (iii) cleaving the ester group at the 17.alpha.-position to generate a 17.alpha.-hydroxy group.

REFERENCES:
patent: 3728337 (1973-04-01), Barton

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