Method of making poly(propylene fumarate-coethylene oxide)

Details Method of making poly(propylene fumarate-coethylene oxide) Method of making poly(propylene fumarate-coethylene oxide)

1996-04-24

1997-07-01

Acquah, Samuel A.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

528300, 528302, 528306, 525437, 525445, 524356, 524539, 524770, C08F 2000

Patent

active

056440057

ABSTRACT:
A biodegradable block copolymer made from the transesterfication of a poly(propylene fumarate) prepolymer and a poly(ethylene oxide) prepolymer. The block copolymer poly(propylene fumarate -co- ethylene oxide) is capable of crosslinking at body temperature. Crosslinking requires an appropriate crosslinking monomer and an initiator. The biodegradable block copolymer has utility as a vascular implant became it can be injected as a fluid into the vascular system and crosslinked in situ.

REFERENCES:
patent: 4888413 (1989-12-01), Domb
patent: 5213580 (1993-05-01), Slepian et al.
A.J. Domb et al., "The Formation of Propylene Fumarate Oligomers for Use in Bioerodible Bone Cement Composites," Journal of Polymer Science: Part A: Polymer Chemistry, vol. 28 (1990), pp. 973-985.
J. M. Harris, "Introduction to Biotechnical and Biomedical Applications of Poly(Ethylene Glycol)," Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications, 1992, pp. 1-3.
A.S. Sawhney et al., "Bioerodible Hydrogels Based on Photopolymerized Poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) Diacrylate Macromers," Macromolecules, 1993, 26, pp. 581-587.

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