Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-09-10
1997-07-01
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514546, 514643, 514646, A61K 31195
Patent
active
056439547
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/RU92/0005 filed Jan. 10, 1992.
FIELD OF TECHNOLOGY
The present invention relates to medicine, more specifically, to a new medicinal preparation of antistress, stress-protective and nootropic effect.
PRIOR ART
The most frequent reaction of a person in a stress situation is psycho-emotional strain accompanied by excitement, anxiety, the worsening of memory and attention and is manifested in irrational, inadequate forms of behaviour, in the decline and disorders of mental capacity, speed of reaction, in the increased number of erroneous decisions etc. Similar disorders are observed in various diseases (neuroses, neurosis-like states, astheno-neurotic reactions, to mention just few), and what is more, the degree of these disorders is increased in the case of acute and chronic stress influences.
In this connection, of substantial importance is a search for and preparation of drugs abating and preventing the effect of a stress factor and also displaying nootropic properties (increasing attention improving memory and mental capacity and also stability of the brain to agressive influences).
Inasmuch as psycho-emotional strain is the response of a human body to various excessive stimuli, then for purposes of eliminating this strain, use is made of calming drugs with tranquilizers of the benzdiasepine seties being widely known and most frequently used, as well as the derivatives of gammaamino-butyric acid (GABA)-phenibute, baclophene, lyoresal which at the same time exhibit a nootropic effect (D. Mashkovsky. "Medicinal drugs", Moscow, MEDITSINA Publishers, 1988, part I, pp. 70-79, 122-123). However, the above-identified tranquilizers and derivatives (GABA) possess serious side-effects. Their doses are accompanied by drowsiness, depression, dizziness, lowered psychomotor reactions, an awkward gait, menstrual cycle disorders, libido and is contraindicated for the persons whose behaviour requires rapid and exact psychic and motor reactions. Besides this, a prolonged use of tranquilizers affects mental working capacity and forms toxicomania.
A number of GABA derivatives are widely known and applied as nootropic drugs; however, they do not possess the antistressor or stress-protective effect (Mashkovsky. "Medicinal drugs", 1988, Meditsina Publishers, part I, pp. 117, 123).
It is known to use glycine as an ingredient of the preparation Mega 3 Vitamins/Minerals, the firm Ortho-Biotics, which is used in stress states and also for enhancing intellectual working capacity (Professional Ortho-Biotics, Catalogue 1989, CH, 1203 Geneva, Pharmacie Des Charmilles, p. 18). Alongside with said glycine, however, this preparation incorporates over 34 different ingredients, including vitamins, displaying an allergizing effect and has high cost price. Moreover, it contains a tryptophan whose application in pharmaceuticals and food additions has currently been prohibited by EDA (December of 1989).
DISCLOSURE OF THE INVENTION
The claimed preparation is a new one and has not yet been described in literature. It is the principal object of the invention to develop a new medicinal drug possessing antistress, stress-protective and nootropic effects and also high activity; more than that, it is non-toxic and produces no side-effects.
The task has been solved owing to the fact that the claimed preparation comprising an active substance and a pharmaceutical carrier contains, according to the invention, the active substance represented by an amino-acid-glycine (glycocol, aminoacetic acid) of the following formula: ##STR1## The preparation under examination demonstrates a highly effective antistress, stress-protective and nootropic effects and finds a variety of applications in the prophylaxis and treatment of neuroses and neurosis-like states, the residual phenomena of craniocerebral injuries and neuroinfections, astheno-vegetative disorders, in case of chronic alcohol intoxication and alcoholic abstinence and also for enhancing mental capacity.
The medicinal preparation can be used in the form of a powder,
REFERENCES:
patent: 4438114 (1984-03-01), Blackburn et al.
patent: 4438144 (1984-03-01), Blackburn et al.
patent: 4562205 (1985-12-01), Cavalier
patent: 4871550 (1989-10-01), Millman
Refcrativny Zhurnal "Khimia" vol. 19, No. 22, Viniti, 1991 p. 60, Abstract No. 22 0214 P.
Abstracts Journal 19. Chemistry, 190, Technology of Organic Medicinal Agents, Veterinary Agents and Pesticides, Moscow, 1991, Entries 220211 to 220219.
The Merck Index, 10th Ed. (1983) Abstract No. 5917.
Burbenskaya Natalya Mikhailovna
Gudkova Julia Vasileivna
Komissarova Irina Alexeevna
Kondrashova Tatyana Tikhonovna
Soldatenkova Tatyana Dmitrievna
LandOfFree
Method of preventing and alleviating stress in a healthy mammal does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of preventing and alleviating stress in a healthy mammal , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of preventing and alleviating stress in a healthy mammal will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-597732