Process for preparing 4-oxo-4,5,6,7-tetrahydrobenzofuran

Details Process for preparing 4-oxo-4,5,6,7-tetrahydrobenzofuran Process for preparing 4-oxo-4,5,6,7-tetrahydrobenzofuran

1983-08-04

1985-12-10

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30779

Patent

active

045581436

ABSTRACT:
A 4-oxo-4,5,6,7-tetrahydrobenzofuran derivative is prepared by reacting a 1,3-cyclohexanedione derivative with chloroacetaldehyde in the presence of a base while maintaining the reaction mixture at a pH of from 4 to 10, and treating the reaction mixture with an acid. The 4-oxo-4,5,6,7-tetrahydrobenzofuran derivatives are useful as an intermediate for synthesis of various kinds of drugs.

REFERENCES:
Besagni et al., Bull. Soc. Chim. France, pp. 4041-4047 (1971).

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