Method of using N-arylheteroarylalkyl imidazol-2-one compounds f

Details Method of using N-arylheteroarylalkyl imidazol-2-one compounds f Method of using N-arylheteroarylalkyl imidazol-2-one compounds f

1993-07-01

1997-07-01

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5462724, 5462744, 514337, 514340, 514345, 514346, 514350, 514351, 514318, 514326, A61K 31535, A61K 31505, A61K 31445, A61K 31411

Patent

active

056439067

ABSTRACT:
A class of N-arylheteroarylalkyl imidazol-2-one compounds is described for use in treatment of a glaucoma disorder. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein A is selected from ##STR2## wherein R.sup.1 is selected from hydrido and alkyl; wherein each of R.sup.2, R.sup.3 and R.sup.4 is independently selected from hydrido, alkyl, alkoxy, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; wherein R.sup.5 is hydrido; wherein R.sup.6 is alkyl; wherein R.sup.7 is an acidic group selected from COOH and ##STR3## or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof.

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