Application of protein-protein interaction as an assay for the d

Details Application of protein-protein interaction as an assay for the d Application of protein-protein interaction as an assay for the d

1978-03-07

1980-11-18

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 426 60, A23J 118, C07G 703

Patent

active

042344760

ABSTRACT:
A specific type of protein, which has been designated B-protein (Bucovaz-protein), is present in most serum of individuals with cancer. The B-protein interacts with a low molecular weight protein component, which is released by the coenzyme A-synthesizing protein complex (CoA-SPC) of Bakers' yeast during the course of CoA synthesis. This low molecular weight protein, for purposes of identification, is referred to as binding protein. The binding protein has a molecular weight of 10,000 to 15,000. Interaction of radioactively labeled binding protein of CoA-SPC with the B-protein of serum provides a marker for the detection of cancer. Of 3005 serums assayed, which included 908 patients diagnosed as having cancer, the B-protein assay agreed with the clinical diagnosis in more than 89% of the cases.

REFERENCES:
patent: 3663684 (1972-05-01), Freedman et al.
patent: 3697638 (1972-10-01), Hansen
patent: 3869436 (1975-03-01), Albinsson
patent: 3888839 (1975-06-01), Newell et al.
patent: 3935072 (1976-01-01), Chibata et al.
patent: 4079048 (1978-03-01), Chao
patent: 4080260 (1978-03-01), Chao
Bucovaz et al., Proc. Am. Assoc. Cancer Research, vol. 16 (1975), p. 80, Abstract #318.

Affiliated with

Also associated with

Rating

Application of protein-protein interaction as an assay for the d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Application of protein-protein interaction as an assay for the d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Application of protein-protein interaction as an assay for the d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-597132