Oral vaccines

Details Oral vaccines Oral vaccines

Filed on

1994-07-29

Date issued

1997-07-01

Examiner

Smith, Lynette F.

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Antigen, epitope, or other immunospecific immunoeffector

SubSubClass

Virus or component thereof

Other Related Categories

4242051, 4242181, 4241891, 4242331, 435 691, A61K 3929, A61K 3912, A61K 3923, C12P 2106

Type

Patent

Status

active

Patent number

056435797

Description

ABSTRACT:
Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.

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Smith et al., Nature, 302, 490 (1983).
Kalica et al., Virology, 112, 385 (1981).
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Elleman et al., Nucleic Acids Res. 11, 4689 (1983).
Kitchingman, Gene, 20, 205 (1982).
Davis, et al, 1985, "Expression of hepatitis B . . . " PNAS 82:7560-7564.
Hung, et al, 1988, "Adenovirus as the carrier . . . " Tech. Advances in Vacine Dev. : 267-277.
Richardson, et al, 1984, "Nucleotide sequence of the gene . . . " J. Virol. 51(3) : 860-862.
Lubeck, et al, 1989, "Immunogenicity and efficacy testing . . . " PNAS 86 : 6763-6767.
Morin, et al, 1987, "Recombinant adenovirus induces antibody . . . " PNAS 84: 4626-4630.
Virology, Ginsberg, "Reoviruses and Epidemic Acute Gastroenteritis Viruses": Rotaviruses, pp. 315-318, 1988.

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