Valproate conjugation using dicarbonyls

Details Valproate conjugation using dicarbonyls Valproate conjugation using dicarbonyls

1980-07-14

1982-04-06

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032642, 26034674, 260333, 560142, 560190, 562577, 562590, C07D30910, C07C 5974, C07C 5502

Patent

active

043235077

ABSTRACT:
.alpha.-substituted derivatives of valproic acid are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of valproate, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of valproate. The compounds are synthesized by alkylating valproate at the tertiary carbon atom by an aliphatic chain with a terminal double bond which is cleaved to provide an acid or aldehyde group.

REFERENCES:
patent: 2444735 (1948-07-01), Hagemeyer, Jr.
patent: 3646126 (1972-02-01), Richtzenhain et al.
Alles et al., Journal of the Chemical Society, (1956) p. 797.
Bhattacharyya, Current Science of India, No. 11, (1952) pp. 312-313.
Burger's Medicinal Chemistry, Fourth Edition Part II, John Wiley, p. 675 (1979).

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