Purified antineoplaston fractions and methods of treating neopla

Details Purified antineoplaston fractions and methods of treating neopla Purified antineoplaston fractions and methods of treating neopla

1984-08-20

1985-12-10

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546220, A61K 3700, C07D21140

Patent

active

045580570

ABSTRACT:
Highly purified fractions from human urine exhibiting antineoplastic activity and processes for their preparation are described. The fractions comprise biologically active, small sized, low molecular weight peptides which exert cytostatic and cytotoxic activity toward neoplastic cell cultures and human neoplastic diseases. The fractions have been termed antineoplaston fractions. An antineoplastic active peptide common to each of the various antineoplaston fractions has been isolated and identified as 3-[N-phenylacetylaminopiperidine]-2, 6-dion. A synthetic mechanism for the preparation of 3-[N-phenylacetylaminopiperdine]-2, 6-dion is also disclosed, involving a combination reaction between L-glutamine and phenylacetyl chloride. Also disclosed are the hydrolysis degradation products of 3-[N-phenylacetylaminopiperidine]-2, 6-dion which also exhibit antineoplastic activity when administered according to the general teachings presented in this disclosure.

REFERENCES:
patent: 4470976 (1981-12-01), Burzynski
Stein, W. H. et al., "Phenylacetylglutamine as a Constituent of Normal Human Urine", J. Amer. Chem. Soc., 70:2848-9, (1954).
Burzynski, S. R. et al., "Purification, Structure Determination, Synthesis and Animal Toxicity Studies of Antineoplaston A10", 13th International Congress of Chemotherapy, (Aug.-Sep. 1983).
Antineoplastons, Unlisted Drugs, 28:133, (Aug. 1976).
Kamerling, J. P. et al., "Gas Chromatography of Urinary N-Phenylacetylglutamine", J. Chromatography, 164:217-221, (1979).
Pinkston, D., J. Chromatography, 223:1-19, (1981).

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