Process for the preparation of solutions of 7-aminocephalosporan

Details Process for the preparation of solutions of 7-aminocephalosporan Process for the preparation of solutions of 7-aminocephalosporan

1981-11-20

1983-09-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 16, 544 23, 424246, C07D50118, A61K 31545

Patent

active

044057822

ABSTRACT:
A process for the preparation of solutions of 7-aminocephalosporanic acids wherein there is obtained a salt of the general formula III: ##STR1## where R.sub.1 may be a group selected from among hydrogen, methyl, or a low molecular weight alkoxy, R.sub.2 is a group selected from among methyl, methoxy, azido, chlorine, carbamoylmethyl, acetoxy, thiomethyl, phenylthiomethyl and others, x means from 3 to 5 carbon atoms and y means from 2 to 4 carbon atoms is disclosed. The process is based on the reaction of a compound of formula I ##STR2## with a bicyclic amidine.

REFERENCES:
patent: 3965098 (1976-06-01), Robinson
patent: 4051131 (1977-09-01), Robinson

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