Piperazine derivatives

Details Piperazine derivatives Piperazine derivatives

1981-01-19

1983-09-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544368, 544366, 548256, 548259, C07D41300, A61K 31495

Patent

active

044056206

ABSTRACT:
Compounds of the formula (I), or pharmaceutically acceptable salts thereof ##STR1## wherein X is phenyl, optionally substituted by one halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; or pyridyl; R.sub.1 is hydrogen or C.sub.1-6 alkyl; and n is 1 to 6, pharmaceutical compositions containing them and a process for their preparation. These compounds are useful in the prophylaxis or treatment of diseases due to a histamine-mediated allergic response.

REFERENCES:
Weilheimer, W., "Synthetic Methods of Organic Chemistry", vol. 15, p. 28, (1961).
Burton et al., "Comprehensive Org. Chem., The Synthesis and Reactions of Org. Cpds.", vol. 5, p. 354.
McOmie, J. F., "Protectine Groups in Org. Chem.", p. 198, (1973).
Marsh, et al., J. Org. Chem., 30, 2491 (1965).
Hoover et al., J. Amer. Chem. Soc., 1956, vol. 78, p. 5832-5836.
Wiley et al., J. Org. Chem., 1956, vol. 21, p. 190-192.
Albert, A. D., J. Chem. Soc. Perkin Trans. I, 1978, p. 513-516.
Dorgan et al., J. Chem. Soc. Perkin Trans I, 1980, p. 930, 940.
Chemical Abstracts, Tsuij, T. et al. 89:6100s.
Tetrahedron Letters vol. 21, p. 3731, 1980 Willard et al.
Tetrahedun Letters, vol. 16, p. 1327, 1970 Feutrill et al.

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