Process for preparing fluorinated amino-nitriles

Details Process for preparing fluorinated amino-nitriles Process for preparing fluorinated amino-nitriles

1981-11-16

1983-09-20

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

549442, 260390, 260465E, 2604657, 548344, 548475, 560 38, 562449, 562561, 424319, C07C12000, C07C12143, C07C12145, C07C12178

Patent

active

044055307

ABSTRACT:
Certain .alpha.-(fluoromethyl or difluoromethyl)-.alpha.-aminoacetonitriles are prepared by treating the appropriate .alpha.-(fluoromethyl or difluoromethyl) ketimine magnesium halide with hydrogen cyanide or with an alkali metal cyanide or ammonium cyanide and a proton source. The products are useful as intermediates for making .alpha.-(fluoromethyl or difluoromethyl)-.alpha.-amino acids having pharmacological activity.

REFERENCES:
patent: 4072698 (1978-02-01), Hylton et al.
Kharasch and Reinmuth, "Grignard Reactions of Non-Metallic Substances", (1954), pp. 1204-1223; Prentice-Hall, N.Y.
Patai, "The Chemistry of the Carbon-Nitrogen Double Bond", (1970); pp. 256-258, 266-271, 351-352; Interscience Pub.
Rappoport, "The Chemistry of the Cyano Group", (1970), pp. 276-283; Interscience Pub.

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