Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic a

Details Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic a Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic a

1981-11-30

1983-08-09

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544239, A61K 3150, C07D23704, C07D23714

Patent

active

043978541

ABSTRACT:
Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents.
Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted .gamma.-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product.
The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.

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Luis Pitarch et al., Eur. Med. Chem., Chimica Therapeutica, No. 6, 644, (1974).
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