Process for producing optically active carboxylic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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562405, 562496, 562605, C07B 5300

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055632955

ABSTRACT:
A process for the production of an optically active carboxylic acid (I), which comprises subjecting an olefinic carboxylic acid (II) to asymmetric hydrogenation using a complex as a catalyst consisting of an optically active phosphine (III) and a ruthenium compound.
Complex of ##STR1## with a ruthenium compound ##STR2## According to the process of the present invention, optically active carboxylic acids can be produced with high yield.

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patent: 5190905 (1993-03-01), Kolich et al.
patent: 5198576 (1993-03-01), Scannell
patent: 5206399 (1993-04-01), Sayo et al.
Tetrahedron Letters, vol. 32, No. 49, pp. 7283-7286 (1991).
Journal of the Chemical Society, Perkin Trans., pp. 2309-2322 (1994).

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