Process for the preparation of luciferin compounds

Details Process for the preparation of luciferin compounds Process for the preparation of luciferin compounds

1987-09-10

1989-05-02

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D41704

Patent

active

048269891

ABSTRACT:
The present invention provides a process for the preparation of compounds of the general formula: ##STR1## in which X is a hydroxyl group and X.sub.1 is a hydrogen atom or a hydroxyl group, and especially of luciferin, by the reaction of D-cysteine with 2-cyanomono- or -dihydroxybenzothiazole obtained from 2-chloromono- or -dimethoxybenzothiazole via a demethylation, wherein the demethylation is accomplished by reaction with iodotrimethylsilane or with a mixture of phenyltrimethylsilane and iodine and hydrolysis under mild conditions of the silyl derivative formed.

REFERENCES:
Fusor, Advanced Organic Chemistry, 178-81 (Wiley, 1950).
White et al., "Analogs of Firefly Luciferin", J. Org. Chem. 30, 2344-8 (1965).
Ho et al., "Spaltung von Esters und Ethers mit Iodotrimethylsilan", Argu. Chemie 15, 847 (1976).
Starks, "Phase-Transfer Catalysis. I. Heterogeneous Reactions, . . . ", J.A.C.S. 93, 195-9 (1971).

Affiliated with

Also associated with

Rating

Process for the preparation of luciferin compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of luciferin compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of luciferin compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-586149