Phospholipid derivatives of nucleosides

Details Phospholipid derivatives of nucleosides Phospholipid derivatives of nucleosides

1995-05-09

1996-10-08

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 261, C07H 1910, C07H 1920

Patent

active

055632572

ABSTRACT:
Liponucleotides containing an ether linkage in the 2-position and a thioether, sulfoxide, or sulfone linkage in the 3-position. The nucleoside component of said liponucleotide is AZT or 3'-deoxy-3'-fluorothymidine. These compounds exhibit antiviral activity.

REFERENCES:
patent: 4283394 (1981-08-01), West et al.
patent: 4291024 (1981-09-01), Turcotte
patent: 4622392 (1986-11-01), Hona et al.
patent: 4921951 (1990-05-01), Shuto et al.
patent: 5194654 (1993-03-01), Hostetler et al.
patent: 5223263 (1993-06-01), Hostetler et al.
Hostetler, K. Y., et al., Jour. of Bio. Chem. vol. 265, No. 11, pp. 6112-6117 (1990).
Shuto, S. et al., Tetrahedron Letters, vol. 28, No. 2, pp. 199-202 (1987).
Hong, C. II, et al., J. Med. Chem. vol. 33, pp. 1380-1386 (1990).
Shuto, S., et al., Chem. Pharm. Bull. vol. 36. No. 1, pp. 209-217 (1988).
Shuto, S., et al., Chem. Pharm. Bull. vol. 36, No. 12, pp. 5020-5023 (1988).
Piantadosi, C., et al. J. Med. Chem., vol. 34, pp. 1408-1414 (1991).
Hostetler, K. Y., et al. Journal of Biol. Chem. vol. 266, No. 18, pp. 11714-11717 (1991).
Steim, J. M., et al., Biochem. Biophys. Res. Com., vol. 171, No. 1, pp. 451-457 (1990).
Hong, C. I., et al., Cancer Research vol. 50, pp. 4401-4406 (1990).
Hong, C. I., et al. Lipids, vol. 26, No. 12, pp. 1437-1444 (1991).
Hong, C. I., et al. Drugs of the Future vol. 15, No. 3, pp. 245-253 (1990).
Ryu, E. K., et al. Jour. of Medicinal Chem. vol. 25, No. 11 pp. 1322-1329 (1982).
Lindh, I., et al. Nucleic Acids Res. Symposium Series No. 18 pp. 189-193 (1987).
Meier, C., et al., Bioorganic & Medicinal Chem. Ltrs. vol. 1, No. 10, pp. 527-530 (1991).
Chemical Abstract, Issue 209, 109:93508d, p. 11 (1988).

Affiliated with

Also associated with

Rating

Phospholipid derivatives of nucleosides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phospholipid derivatives of nucleosides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phospholipid derivatives of nucleosides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-58362