Thyroid hormone analogues and methods for their preparation

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514543, 514570, 560 9, 560 52, 560 57, 560 61, 562464, 562471, 562426, C07C 5948

Patent

active

061075175

ABSTRACT:
Thyroid hormone analogues are disclosed. Methods of using such analogues and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.

REFERENCES:
patent: 3332957 (1967-07-01), Bencze
patent: 4072705 (1978-02-01), Mieville
patent: 4323691 (1982-04-01), Ours et al.
patent: 5883294 (1999-05-01), Scanlan et al.
Apriletti et al., "Expression of the Rat .alpha.1 Thyroid Hormone Receptor Ligand Binging Domain in Escherichia coli and the Use of a Ligand-Induced Conformation Change as a Method for Its Purification to Homogeneity," Protein Expression and Purification, vol. 6, pp. 363-370, 1995.
Apriletti et al., "Large Scale Purification of the Nuclear Thyroid Hormone Receptor from Rat Liver and Sequence-Specific Binding of the Receptor to DNA," J. Biol. Chem., vol. 263, No. 19, pp. 9409-9417, 1988.
Chiellini et al., "A High-Affinity Subtype-Selective Agonist Ligand for the Thyroid Hormone Receptor," Chemistry and Biology, vol. 5, No. 6, pp. 299-306, 1998.
Luengo et al., "Manipulation of the Rapamycin Effector Domain. Selective Nucleophilic Substitution of the C.sub.7 Methoxy Group," J. Org. Chem., vol. 59, pp. 6512-6513, 1994.
Luengo et al., "Structure-Activity Studies of Rapamycin Analogs: Evidence that the C-7 Methoxy Group Is Part of the Effector Domain and Positioned at the FKBP12-FRP Interface," Chemistry and Biology, vol. 2, pp. 471-481, 1995.
Ribeiro et al., "Mechanisms of Thyroid Hormone Action: Insights from X-ray Crystallographic and Functional Studies," Recent Progress in Hormone Research, vol. 53, 351-394, 1998.
Ribeiro et al., "Thyroid Hormone Export Regulates Cellular Hormone Content and Response," J. Biol. Chem., vol. 271, No. 29, pp. 17147-17151, 1996.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Thyroid hormone analogues and methods for their preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thyroid hormone analogues and methods for their preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thyroid hormone analogues and methods for their preparation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-582913

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.