Process for making optically active .alpha.-amino ketones and se

Details Process for making optically active .alpha.-amino ketones and se Process for making optically active .alpha.-amino ketones and se

1995-10-10

2000-08-22

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 39, 560 40, 560 41, 562170, 562445, C07C22900

Patent

active

061075124

ABSTRACT:
The invention includes selected novel optically active .alpha.-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.

REFERENCES:
patent: 4277420 (1981-07-01), Koenig
patent: 4316847 (1982-02-01), Batcho et al.
patent: 4906773 (1990-03-01), Taketomi et al.
patent: 4912221 (1990-03-01), O'Reilly et al.
patent: 4916252 (1990-04-01), Sayo et al.
patent: 4939288 (1990-07-01), Talley
patent: 5086165 (1992-02-01), Marshall et al.
G. Sholom et al, Proc. Natl. Acad.Sci.USA, 85, 684-688 (1988).
A. Ewenson et al, J. Med. chem. 31, 416-421, (1988).
S. Ouchi et al, J. of Antiobiotics, 1576-1580, (1983).
M. Garcia-Lopez et al, Tet. Lett., 29, 1577-1580 (1988).
R. Meyer et al, J. Med. Chem., 25, 996-999 (1982).
R. Almquist et al, J. Med. Chem., 26, 1292-1299 (1982).
J. McMurray et al, J. Org. Chem., 50, 1112-1115 (1985).
A. Ewenson et al, Int. J. Peptide Protein Res., 31, 269-280 (1988).
R. Almquist et al, J. Med. chem., 27, 115-120 (1984).
R. Johnson et al, Int. J. Peptide Protein Res., 23, 581-590 (1984).
C. Jennings-White et al, Tet. Lett., 23, 2533-2534 (1982).
M. Holladay et al, Tet. Lett., 24, 4401-4404 (1983).
W. Knowles et al, J. Am. chem. Soc., 99:18, 5946-5952 (1977).
H. Kagan et al, J. Am. Chem. Soc., 94:18, 6429-6433 (1972).
J. Brown et al, Synthesis, 350-352 (1979).
H. Brunner et al, Chem. Ber., 114, 1137-1149 (1981).
R. Almquist et al, J. Med. chem., 23, 1392-1398 (1980).
Spatola, A.F., "Chemistry & Biochemistry Amino Acids, Peptides and Proteins" Weinstein, B., Marcel Dekker, N.Y. 1983, pp. 267-357.
R.G. Almquist et al, J. Med. Chem., 27, 115-120 (1984).
A. Ewenson et al, J. Med. Chem., 29, 295-299 (1986).
CA 116: 129589 (1992).
CA 109: 190803 (1988).

Affiliated with

Also associated with

Rating

Process for making optically active .alpha.-amino ketones and se does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for making optically active .alpha.-amino ketones and se, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for making optically active .alpha.-amino ketones and se will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-582881