Use of arginine as an lymphokine synergist

Details Use of arginine as an lymphokine synergist Use of arginine as an lymphokine synergist

1987-10-09

1989-11-28

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 424 854, 424 855, 424 856, 424 857, 514 2, 514 8, 514 21, 514885, 435811, 530351, A61K 3702, A61K 4502

Patent

active

048836613

ABSTRACT:
It has been found that arginine serves to increase the receptivity of cells to lymphokines such as interleukin-2 and interferon. An improved method for treating a mammal with one or more lymphokines is disclosed wherein said improvement comprises administering said one or more lymphokines to said mammal in combination with an amount of arginine effective to increase the receptivity of cells of said mammal to said one or more lymphokines.

REFERENCES:
patent: 4222907 (1980-09-01), Katz
Adrian Barbul, "Arginine: Biochemistry, Physiology, and Therapeutic Implications", Journal of Parenteral and Entereal Nutrition 10: 227-238 (1986).
Varner, CA, vol. 92, 1980, #161571b.
Chany et al., CA, vol. 98, #155213u, 1983.
Chany et al, CA, vol. 98, #11168r, 1982.
Brunetti et al, CA, vol. 108(5), 1987, #38436l.
Cerutti et al, CA, vol. 103(23), 1985, #189307q.
Varner, et al., "Temporal Serum Concentrations of Growth Hormone, Thyrotropin, Insulin, and Gucagon in Sheep Immunized Against Somatostatin", Endocrinology, vol. 106, No. 3, 1027-1032 (1980).
Cerutti, et al., "Importance of Coordinated Immune Stimulation in Experimental Antitumor Treatment", Int. J. Immunopharmac, vol. 7, No. 5, 783-787 (1985).
Chany, et al., "Antitumor Effect of Arginine Butyrate in Conjunction with Corynebacterium Parvum and Interferon", Int. J. Cancer, vol. 30: 489-493 (1982).

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