Process for isolating coagulation factors, and adsorbent materia

Details Process for isolating coagulation factors, and adsorbent materia Process for isolating coagulation factors, and adsorbent materia

1988-08-03

1989-11-28

Jones, W. Gary

Liquid purification or separation

Processes

Chromatography

2101982, 2105021, 210691, 210692, 502402, 502404, 530381, 530413, 536 187, B01D 1508

Patent

active

048835986

ABSTRACT:
This invention relates to a process and to absorbent material for isolating coagulation factors, including FVIII and vWF, from the example blood plasma and plasma products by means of liquid chromatography. The adsorbent material comprises a polymeric carrier to which amino groups are linked as ligands through spacers. The spacers have a chain length of at least 6 atoms and contain at least one hydrophilic link within the chain. The spacers preferably have the formula --(CH.sub.2).sub.m --CO--NH--(CH.sub.2).sub.n -- wherein m and n each represent an integer of 1-6 and m+n is at least 4. The spacers are preferably linked to the carrier through --CO--NH-- groups. The ligand density in the absorbent material is preferably higher than 30 umoles/ml of swollen matrix.

REFERENCES:
patent: 3947352 (1976-03-01), Cuatvecasas et al.
patent: 4086222 (1978-04-01), Lindquist et al.
patent: 4090919 (1978-05-01), Chibata et al.
patent: 4663163 (1987-05-01), Hou et al.

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