Device for determination of tear constituents

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Calorimeter

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422 61, G01N 2100

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active

053524110

ABSTRACT:
A device for determination of a tear constituent, including an absorbent tear strip wick and an electrochemical strip connected to one end of the wick. The electrochemical strip is impregnated with an indicator chemistry. The device may be used to detect organic and ionic constituents in tears by placement of the free end of the tear strip wick in the corner of the eye, and after tear absorption by the device, determining changes in the chemistry of the device associated with the particular constituent.

REFERENCES:
patent: 4994751 (1991-02-01), Cook et al.
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Avisar, R., H. Savir, Y. Sidi, and J. Pinkhas, Tear Calcium and magnesium levels of normal subjects and patients with hypocalcemia or hypercalcemia, Invest. Ophthamol. 16:1150-1151 (1977).
Van Haeringen, N. J. and E. Glasius, Collection Method Dependent Concentrations of Some Metabolites in Human Tear Fluid, with Special Reference to Glucose Hyperglycaemic Conditions, Albrecht von Graefes Arch. Klin. Ophthmol. 202:1-7 (1977).
Van Haeringen, N. J., Clinical Biochemistry of Tears, published 1981.
Desai, B. M., and B. C. Lavingia-Ahmedabad. Cornea Thickness and Tear Glucose Levels in Diabetes Millitus and Normal Persons, Ind. J. Ophth. 35:130-132 (1987).
Romano, A. and F. Rolant, A Non-Invasive Method of Blood Glucose Evaluation by Tear Glucose Measurement, for the Detection and Control of Diabetic States, Metabolic, Pediatric and Systemic Ophthamol. 11:78-80 (1988).
Kang, J., G. Fulop and A. H. Friedman, Tear urea nitrogen and creatinine levels in renal patients, Acta Ophthalmol. 66:407-412 (1988).
Rolando, M., F. Baldi, and G. Calabria, Tear Mucus Crystallization in Children with Cystic Fibrosis, Oppthalmologica 197:202-206 (1988).
Maurice, D., The Charles Prentice Award Lecture 1989: The Physiology of Tears, Optometry and Vision Science 67:391-399 (1990).

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