Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1988-04-28
1994-03-01
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
424 93L, 935 47, 435 697, C07K 1300, C12P 2106, C12N 1500
Patent
active
052909140
ABSTRACT:
The invention concerns novel hybrid pesticidal toxins. These toxins are expressed as the fusion protein of a chimeric gene. Specifically exemplified is a novel B.t. hybrid toxin. These novel toxins have increased toxicity against target pests. The invention also concerns a process for preparing a hybrid virus having an altered insect host range.
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Knowles, B. H., W. E. Thomas and D. J. Ellar (1984) "Lectin-Like Binding or Bacillus thuringiensis var kurstaki Lepidopteran-Specific Toxin is an Initial Step in Insecticidal Action," FEBS 168(2):197-202.
Schnepf, H. E., and H. R. Whiteley (1985) "Delineation of a Toxin-Encoding Segment of a Bacillus thuringiensis Crystal Protein Gene," J. Biol. Chem. 260:6273-6290.
Pennock et al. "Strong and Regulated Expression of Escherichia coli .beta.Galactosidase in Insect cells . . . " Molec. and Cell. Biology vol. 4, #3 pp. 399-406 1984.
Stirpe, et al "Ribosome-Inactivating Proteins up to date" FEBS 3269 vol. 195, Nos. 1,2, pp. 1-8 1986.
Culver Paul
Edwards David L.
Schwab George E.
Thompson Mark
Wilcox Edward
Hendricks Keith D.
Mycogen Corporation
Wax Robert A.
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