Illudin analogs useful as antitumor agents

Details Illudin analogs useful as antitumor agents Illudin analogs useful as antitumor agents

1994-07-15

1996-10-08

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

560162, 560255, 560256, 568374, A61K 3112, C07C 49403

Patent

active

055631762

ABSTRACT:
Antineoplastic illudin analogs are provided of the formula: wherein R.sub.4, R.sub.5 and R.sub.6 are (C.sub.1 -C.sub.4)alkyl, Y is H, (C.sub.1 -C.sub.3)alkyl, (R.sub.4)R.sub.5)(R.sub.6)Si or alkanoyl ((C.sub.1 -C.sub.4)alkylC(O)) and R is CH.sub.2 OH, halo, benzyl optionally substituted with OY, or alkanoylmethyl (CH.sub.2 OC(O)R.sub.7), wherein R.sub.7 is (C.sub.1 -C.sub.4)alkyl, (C.sub.6 -C.sub.2)aryl or N(X).sub.2, wherein each X is H or (C.sub.1 -C.sub.4)alkyl, and the pharmaceutically-acceptable salts thereof.

REFERENCES:
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