Tetrazole derivatives

Details Tetrazole derivatives Tetrazole derivatives

1980-07-11

1985-01-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424270, 548161, 548190, 548198, 548252, 548254, C07D25704

Patent

active

044915870

ABSTRACT:
6-(1H-Tetrazol-5-yl)thiazolo[3,2-a]pyrimidin-5-ones, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones, and the corresponding imidazo- and triazolo- pyrimidines, thiones, and imines are useful as antiallergy and antiasthmatic compounds by virtue of their inhibitory action on the immediate hypersensitivity reaction in mammals and relaxant action on the tracheal muscle. Intermediates in the synthesis of these substances from 2-aminoazoles and ethoxymethylene malononitrile also have smooth muscle relaxant and immediate hypersensitivity reaction inhibitory activity.

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