Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an...
Patent
1992-03-17
1994-03-01
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an...
424 9463, C12N 1114, A61K 3754
Patent
active
052906922
ABSTRACT:
A fibrinolytic enzyme such as urokinase, tissue plasminogen activator or streptokinase is covalently bounded to a bioadaptable porous crystalline glass to produce a thrombolytic material. Production of the glass involves combining 40-50 mol% calcium oxide, 20-30 mol% titanium dioxide and 25-35 mol% diphosphorous pentoxide to form a mixture, and combining the mixture with 0.5-4.0 mol% disodium oxide. A bioreactor for converting plasminogen in blood into plasmin can be prepared by packing the material in a column. When finely comminuted, the material can be administered into the blood of a patient for removing blood clots.
REFERENCES:
patent: 4764466 (1988-08-01), Suyama et al.
patent: 5178901 (1993-01-01), Toriyama et al.
Biochim. Biophys. Acta. vol. 24 (1957), pp. 278-282, Jorgen Ploug, et al. Urokinase An Activator Of Plasminogen From Human Urine.
Agric. Biol. Chem. 55(5), pp. 1225-1232 (1991), Yasuhara Itagaki, et al. Purification & Characterization of Tissue Plasminogen Activator Secreted By Human Embryonic Lung Diploid Fibroblasts, IMR-90 Cells.
Biotechnology and Bioengineering, vol XXI pp. 461-476 (1979) John Wiley & Son's, Inc., Y. K. Cho, et al. Immobilization Of Enzymes On Activated Carbon: Selection Preparation Of The Carbon Support.
Science, vol. 166, pp. 615 to 617 (1969), Howard H. Weetall, Trypsin And Papain Covalently Coupled To Porous Glass: Preparation And Characterization.
Kawamoto Yukari
Kawamura Sukezo
Suzuki Takahiro
Toriyama Motohiro
Yokogawa Yoshiyuki
Agency of Industrial Science & Technology, Ministry of Internati
Naff David M.
LandOfFree
Bioadaptable porous crystalline glass containing an immobilized does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bioadaptable porous crystalline glass containing an immobilized , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bioadaptable porous crystalline glass containing an immobilized will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-576366