Diagnostic kit for diagnosing and distinguishing chest pain in e

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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422 56, 422 58, 435 794, 435970, 435973, 435975, 436514, 436528, 436530, 436807, 436808, 436810, G01N 33573, G01N 33558

Type

Patent

Status

active

Patent number

052906787

Description

ABSTRACT:
A diagnostic test kit is disclosed for assessing whether patient chest pain is cardiac in origin and for differentiating between unstable angina and myocardial infarction at early onset of patient chest pain. The test kit comprises a receptacle for receiving and retaining a sample of blood or serum of the patient and at least three monoclonal or polyclonal antibodies suspended on a carrier. Each antibody is complementary to a different protein released by the heart muscle during early stages of a myocardial infarction and has corresponding reagents which are independently responsive to each antibody reacting the complementary protein. The combined response of reagents indicates the diagnostic condition of the patient.

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patent: 5087556 (1992-02-01), Ertinghausen
E. Hoberg, H. A. Katus, K. W. Diederich and W. Kubler, Myoglobin, creatine kinase-B isoenzyme, and myosin light chain release in patients with unstable angina pectoris, European Heart Journal (1987), pp. 990-994.
Speicher et al., "Cardiovascular Subproblems", in Choosing Effective Laboratory Tests, W. B. Saunders Co., Philadelphia (1983), pp. 155-163.
Reese et al., CMA Journal, vol. 124, (1981), pp. 1585-1588.
Katus et al., Am. J. Cardiology, vol. 54, (1984), pp. 964-970.
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Katus et al., am. J. Cardiol., vol. 21, (1989), pp. 1349-1353.
Cummins et al., Am. Heart J., vol. 113, No. 6, (1987), pp. 1333-1344.

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