6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics

Details 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics 6-(Pyridinyl)-3(2H)-pyridazinones and their use as cardiotonics

1980-04-28

1981-12-08

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544239, C07D23714, A01K 3150

Patent

active

043047777

ABSTRACT:
2-R-6-PY-3(2H)-pyridazinones (I) or salts thereof, which are useful as cardiotonics, where R is hydrogen, lower-alkyl or lower-hydroxyalkyl, and PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents, are prepared by reacting 2-R-4,5-dihydro-6-PY-3(2H)-pyridazinone with a dehydrogenating agent. Also shown are: cardiotonic compositions and a method for increasing cardiac contractility using I or salts; and, the preparation of the corresponding intermediate 4,5-dihydro compounds.

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Curran et al. II, J. Med. Chem. 17, 273 (1974).
Haginiwa et al., Chem. Abs. 88, 170096 (1978).
Steck et al., J. Amer. Chem. Soc., 75, 1117 (1953).

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