Process for substitution of aromatic organic compounds

Details Process for substitution of aromatic organic compounds Process for substitution of aromatic organic compounds

1983-06-13

1985-01-22

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 62, 549462, 549475, 549 52, 568315, 568433, 568630, 568632, 568650, 568653, 568656, 568648, 548472, 548542, C07D21516, C07C 4116

Patent

active

044953534

ABSTRACT:
The invention relates to a process for substituting for a halogen atom attached to the nuclear carbon atom of an aromatic ring, a substituent of the formula -O-R wherein R represents alkyl, alkenyl, alkynyl or benzyl, which process comprises reacting the halogen-substituted aromatic compound with an alcoholate of the formula M.sup.n+ [O--R].sub.n.sup..crclbar. wherein M is an alkali metal atom or alkaline earth metal atom, n is the valency of M, and R is as defined above, in the presence of an active catalyst mixture comprising (i) a formic acid ester of an organic alcohol having the formula R.sup.2 --O--CO--H wherein R.sup.2 is as defined for R above; and (ii) a cuprous salt; in a liquid medium which is a solvent for the catalyst mixture and in which the halogen-substituted aromatic compound is at least partially soluble, under substantially anhydrous conditions and a non-oxidizing atmosphere. The invention further relates to a catalyst used in the above process.

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Derwent Abstract of Japanese Patent Publication No. 127,368/80.

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