Stable reagents for the preparation of radio pharmaceuticals

Details Stable reagents for the preparation of radio pharmaceuticals Stable reagents for the preparation of radio pharmaceuticals

1997-10-23

2000-01-18

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548542, 548545, 564148, 564250, 564251, 424 169, C07D40100, C07D27760, C07D25700, A61K 5108

Patent

active

060159049

ABSTRACT:
This invention provides novel reagents for the preparation of radiopharmaceuticals useful as imaging agents for the diagnosis of cardiovascular disorders, infection, inflammation and cancer, diagnostic kits comprising said reagents and intermediate compounds useful for the preparation of said reagents. The reagents are comprised of stable hydrazone modified biologically active molecules that react with gamma emitting radioisotopes to form radiopharmaceuticals that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy.

REFERENCES:
patent: 5066789 (1991-11-01), Srinivasan et al.
patent: 5206370 (1993-04-01), Schwartz et al.
patent: 5362852 (1994-11-01), Geoghegan
patent: 5549883 (1996-08-01), Srinivasan et al.

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