Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-10-20
2000-01-18
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 31195
Patent
active
060158344
ABSTRACT:
A method of reducing the damaging effect of an injury to mammalian cells by treatment of the cell or mammalian tissue in vivo with a cell membrane permeant calcium buffer. The method comprises treating mammalian tissue with a damage reducing effective amount of the calcium buffer, preferably, a BAPTA derivative. The method may be used to control the concentration of Ca.sup.2+ ions in the vicinity of ion channel pores of the cells to prevent diffusion of toxic amounts of Ca.sup.2+ ions to subcellular sites located near the source of Ca.sup.2+ influx. The buffer treatment may be applied as a prophylactic or after the mammalian tissue has sustained injury.
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Charlton Milton P.
Tymianski Michael
Henley III Raymond
Toronto Neuroprotection Group
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