Oligonucleotide synthesis with substituted aryl carboxylic acids

Details Oligonucleotide synthesis with substituted aryl carboxylic acids Oligonucleotide synthesis with substituted aryl carboxylic acids

1994-08-30

1996-11-12

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 261, 536 553, C07H 2100, C07H 2104, C07H 100

Patent

active

055741460

ABSTRACT:
A process for synthesizing oligonucleotides by phosphoramidite chemistry wherein the improvement is the use of substituted aryl carboxylic acids as the activators. These activators produce in situ nucleotide intermediates in which the substituted arylcarbonyl group has displaced the amidite moiety.

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Stec et al. Tetrahedron Letters 25: 5279-5282, 1984.
Hering et al. Nucleosides & Nucleotides 4: 169-171, 1985.
Conte, Maria R., et al; "Solid Phase Synthesis of 5-Hydroxymethyluracil Containing DNA", Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 1, pp. 79-82, 1992.
Beaucage, Serge L., et al; "Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach"; Tetrahedron Report No. 309; Tetrahedron vol. 48, No. 12, pp. 2223-2311, 1992.

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