Pyrimidine compounds and methods of use to derivatize neighborin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514256, 544322, 544323, 544332, A61K 31505, C07D23948

Patent

active

055740405

ABSTRACT:
A compound according to the formula: ##STR1## wherein A=CH.sub.3 or CH.sub.2 CH.sub.3 and ##STR2## wherein X=NH.sub.2, CH.sub.2 or CH.sub.2 CH.sub.3 ; X'=CH.sub.3 or CH.sub.2 CH.sub.3 ; Y=NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2 ; and Z=H, CH.sub.3 or CH.sub.2 CH.sub.3 ; or ##STR3## wherein Y' and Z', indepedently, = H, NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2 or N.sup.+ (CH.sub.3).sub.3 ; and salts thereof.

REFERENCES:
patent: 4705790 (1987-11-01), Hubele et al.
patent: 4814338 (1989-03-01), Ito et al.
patent: 4975530 (1990-12-01), Tzikas et al.
patent: 4988704 (1991-01-01), Ito et al.
patent: 5118339 (1992-06-01), Tamaru et al.
Adam et al., 1989, "Identification of specific binding proteins for a nuclear location sequence", Nature 337: 276-279.
Brinchmann et al., 1991, "Few Infected CD4.sup.+ T Cells but a High Proportion of Replication-Competent Provirus Copies in Asymptomatic Human Immunodeficiency Virus Type 1 Infection", J. Virol. 65: 2019.
Brown et al., 1987, "Correct Integration of Retroviral DNA In Vitro" Cell 49: 347.
Bukrinsky et al., 1991, "Quiescent T Lymphocytes as an Inducible Virus Resevoir in HIV-1 Infection", Science 254: 423-427.
Bukrinsky et al., 1993, "A Nuclear Localization Signal within HIV-1 matrix protein that governs infection of non-dividing cells", Nature 365: 666-669.
Burkinsky et al., 1992, "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes", Proc. Natl. Acad. Sci. 89: 6580-6584.
Chapel et al., 1992, "Differential Human Immunodeficiency Virus Expression in CD4.sup.+ Cloned Lymphocytes: from Viral Latency to Replication", J. Virol. 66: 3966.
Cuomo, 1994, "Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein", Proc. Natl. Acad. Sci. 91: 6156.
Dabauville, 1988, "Inhibition of Nuclear Accumulation of Karyophilic Proteins in Living Cells by Microinjection of the Lectin Wheat Germ Agglutinin", Exp. Cell Res. 174: 291-296.
Dingwall et al., 1988, " The Nucleoplasmin Nuclear Location Sequence is Larger and More Complex that that of SV-40 Large T Antigen", J. Cell Biol. 107:841-849.
Emerman et al., 1994, "Scientific Correspondence", Nature 369: 108.
Fauci et al., 1991, "Immunopathogenic Mechanisms in Human Immunodeficiency Virus (HIV) Infection", Ann. Int. Med. 114: 678.
Forbes, 1992, "Structure and Function of the Nuclear Pore Complex", Ann. Rev. Cell Biol. 8: 495-527.
Goldfarb et al., 1986, "Synthetic peptides as nuclear localization signals", Nature 332:641-644.
Gorlich, 1994 "Isolation of a Protein Is Essential for the First Step of Nuclear Protein Import", Cell 79: 767.
Guilian et al., 1990, "Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1", Science 250: 1593.
Gulizia et al., 1994, "Reduced Nuclear Import of Human Immunodeficiency Virus Type 1 Preintegration Complexes in the Presence of a Prototypic Nuclear Targeting Signal", J. Virol. 68: 2021-2025.
Heinzinger et al., 1994, "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells", Proc. Natl. Acad. Sci. 91: 7311.
Humphries and Temin, 1974, "Requirement for Cell division for Initiation of Transcription of Rous Sarcoma Virus RNA", J. Virol. 14: 531-546.
Hurt, 1993, "The Nuclear Pore Complex", FEBS Letters 325: 76-80.
Kalderon et al., 1984, "A Short Amino Acid Sequence Able to Specify Nuclear Location", Cell 39:499-509.
Keonig et al., 1986, "Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy", Science 233: 1089.
Lanford, 1986, "Induction of Nuclear Transport with a Synthetic Peptide Homologous to the SV40 T Antigen Transport Signal", Cell 46: 575.
Melchoir, 1993, "Inhibition of Nuclear Protein Import by Nonhydrolyzable Analogues of GTP and Identification of the Small GTPase Ran/TC4 as an Essential Transport Factor", J. Cell Biol. 123: 1649.
Miller et al., 1994, "The Human Immunodeficiency Virus-1 nef Gene Product: A Positive Factor For Viral Infection and Replication in Primary Lymphocytes and Macrophages", J. Exp. Med. 179: 101-113.
Pantaleo et al., 1993, "HIV Infection is active and progressive in lymphoid tissue during the clinically latent stage of disease" Nature 362: 355-358.
Pante et al., 1993, "The Nuclear Pore Complex", J. Cell. Biol. 122: 977-984.
Price et al., 1988, "The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex", Science 239: 586-592.
Robbins et al., 1991, "Two Interdependent Basic Domains in Nucleoplasmin Nuclear Targeting Sequence: Identification of a Class of Bipartite Nuclear Targeting Sequence", Cell 64: 615-623.
Schnittman, 1989, "The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4", Science 245: 305.
Spina et al., 1994, "The Importance of nef in the Indication of Human Immunodeficiency Virus Type 1 Replication from Primary Quiescent CD4 Lymphocytes", J. Exp. Med. 179: 115-123.
Sterne-Marr et al., "O-linked Glycoproteins of the Nuclear Pore Complex Interact with a Cytosolic Factor Required for Nuclear Protein Import", 1992, J. Cell Biol. 116: 271.
Stevenson et al., 1990, "HIV-1 replication is controlled at the level of T cell activation and proviral integration", EMBO J. 9: 1551-1560.
Stochaj et al., 1992, "Nucleocytoplasmic traffic of proteins", Eur. J. Cell Biol. 59: 1-11.
Von Schwedler et al., 1994, "The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes", Proc. Natl. Acad. Sci. 91: 6992-6996.
Weinberg, 1991, "Productive Human Immunodeficiency Virus Type 1 (HIV-1) Infection of Nonproliferating Human Monocytes", J. Exp. Med. 172: 1477-1482.
Weiss, 1993, "How Does HIV Cause AIDS", Science 260: 1273.
Wiley et al., 1986, "Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients", Proc. Natl. Acad. Sci. 83: 7089-93.
Yano et al., 1992, "Cloning and Characterization of SRP1, a Supressor of Temperature-Sensitive RNA Polymerase I Mutations, in Saccharomyces cerevisiae", Mol. Cell. Biol. 12: 5640.
Yeh, 1990, "The Arginine-Rich Domain of Hepatitis B Virus Precore and Core Proteins Contain a Signal For Nuclear Transport", Journal of Virology 64: 6141-6147.
Zack, 1990, "HIV`Entry into Quiescent Primary Lymphocytes: Molecular Analysis Reveals a Labile, Latent Viral Structure", Cell 61: 213-222.
Zack et al., 1992, "Incompletely Reverse-Transcribed Human Immunodeficiency Virus Type 1 Genomes in Quiescent Cells Can Function as Intermediates in the Retroviral Life Cycle", J. Virol. 66: 1717-1725.
Zacksenhaus et al., 1993, "A Bipartite Nuclear Localization Signal in the Retinoblastoma Gene Product and Its Importance for Biological Activity", Mol. Cell Biol. 13: 4588.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyrimidine compounds and methods of use to derivatize neighborin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrimidine compounds and methods of use to derivatize neighborin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidine compounds and methods of use to derivatize neighborin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-562808

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.