Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-09-10
1996-11-12
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 58, 514 54, 514 53, 514 59, 514777, 514832, 514833, 435 2, 604 48, 604 49, 604 4, 604 5, 604 6, 604 7, A01N 4304, A01N 2500, A61M 3700, A61M 500
Patent
active
055740197
ABSTRACT:
The present invention relates to the field of compositions of matter, disclosing compositions of matter which as aqueous solutions, may be used to perfuse a living or non-living subject in need of perfusion. The solutions according to the invention are typified by an aqueous solution comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium. The solutions according to the invention are effective substitutes for blood. In addition the solution according to the invention may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution of the invention. The solutions may be used for a number of purposes including maintaining a partially or substantially completely exsanguinated subject at temperatures substantially below those normally maintained by a mammal. The solutions may be used in conjunction with hyperbaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject. Methods for using the solutions for these purposes are disclosed.
REFERENCES:
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patent: 4923442 (1990-05-01), Segall et al.
patent: 4927806 (1990-05-01), Kramer et al.
patent: 5082831 (1992-01-01), Leaf et al.
patent: 5084558 (1992-01-01), Rowan
patent: 5130230 (1992-07-01), Segall et al.
Segall Paul E.
Sternberg Hal
Waitz Harold D.
BioTime, Inc.
Bozicevic Karl
Kight John
Leary Louise N.
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