Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-11-14
1996-11-12
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, 530300, A61K 3800, C07K 500, C07K 700
Patent
active
055740103
ABSTRACT:
A method of inhibiting proliferation of pancreatic tumors. The method involves contacting the pancreatic tumor with an effective amount of peptide YY or an analog of peptide YY.
The method may be used either in vitro or in vivo to reduce tumor cell proliferation. The method is also effective in treating both benign and malignant tumors.
REFERENCES:
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Blackmore et al., Br. J. Cancer, (1992) 66 32-38.
Palmer Smith et al., Am. J. Physiol. (1993) 265 (1, pt. 1) pp. G149-G155.
Harper's Review of Biochemistry, pp. 559-561 (Copyright 1985--Lange Medical Publications).
Laburthe, M., "Peptide YY and Neuropeptide Y in the Gut/Availability, Biological Actions, and Receptors," Trends in Endocrinology and Metabolism, In press, Dec. 1989, pp. 035-041.
R am oet al., "Neuropeptide Y and Peptide YY Stimulate the Growth of Exocrine Pancreatic Carcinoma Cells," Neuropeptides (1990) 15, 101-106.
Playford et al., "Preliminary report: role of peptide YY in defence aainst diarrhoea," The Lancet (1990) 335, 1555-1557.
Evers et al., "Differential Effects of Gut Hormones on Pancreatic and Intestinal Growth During Administration of an Elemental Diet," Ann. Surg. (1990) 211, 5, 630-638.
Sheikh et al., "Localization of Y.sub.1 receptors for NPY and PYY on vascular smooth muscle cells in rat pancreas," Am. Phys. Soc. (1991) G250-G257.
Leiter et al., "Peptide YY/Structure of the Precursor and Expression in Exocrine Pancreas," J. Biol. Chem. (1987) vol. 262, No. 27, pp. 12984-12988.
Balasubramaniam et al., "Structure-Activity Studies of Peptide YY(22-36): N-.alpha.-Ac-[Phe.sup.27 ]PYY(22-36), a Potent Antisecretory Peptide in Rat Jejunum," Peptides (1993) 14, pp. 1011-1016.
Davenport Avis M.
The Regents of the University of California
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