Method of preparation of isopropyl 4,10-dihydro-10-oxothieno[3,2

Details Method of preparation of isopropyl 4,10-dihydro-10-oxothieno[3,2 Method of preparation of isopropyl 4,10-dihydro-10-oxothieno[3,2

1979-02-13

1980-07-08

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 71, C07D49502

Patent

active

042118778

ABSTRACT:
Isopropyl 4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetate is synthesized from 4-(2-carboxy-3-thienylmethoxy)phenylacetic acid by a process comprising acid halide formation, ring closure catalyzed by aluminum trihalide and esterification with isopropyl alcohol. The three reaction steps are carried out successively in the same reactor without any isolation or purification of intermediate products and a surprisingly high overall yield is obtained. Additionally, a valuable chemical, aluminum isopropoxide is obtained as a by-product of this process and significant advantages in terms of environmental pollution and waste water costs are achieved.

REFERENCES:
patent: 4025640 (1977-05-01), McFadden et al.
Aultz et al., Chemical Abstracts, vol. 86, Abst. No. 133,345p (1977).
Degering, An Outline of Organic Chemistry, 6th ed. pp. 86 to 89, Barnes and Noble, Inc., NY (1951).

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