Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1998-09-14
2000-01-18
Chin, Christopher L.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
435332, 5303882, 53038824, 53038823, 5303871, 53038875, A61K 39395, C12N 506, C07K 1600
Patent
active
060155590
ABSTRACT:
The present invention provides a panel of monoclonal antibodies and binding proteins which specifically bind to human Fas antigen. Some of the antibodies and binding proteins are capable of stimulating T cell proliferation, inhibiting binding of anti-Fas CH-11 monoclonal antibody to cells expressing Fas antigen, blocking anti-Fas CH-11 monoclonal antibody-mediated lysis of cells, and blocking Fas ligand-mediated lysis of cells. The invention also provides for therapeutic compositions comprising the monoclonal antibodies.
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D
Alderson Mark R.
Lynch David H.
Anderson Kathryn A.
Chin Christopher L.
Devi S.
Immunex Corporation
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