Liquid purification or separation – Processes – Separating
Patent
1995-06-07
1996-11-12
Reifsnyder, David A.
Liquid purification or separation
Processes
Separating
210361, 210369, 210418, 210424, 210110, 210112, 210115, 494 3, 494 37, 604410, B01D 2126
Patent
active
055736785
ABSTRACT:
Systems and methods for separating mono nuclear cells from whole blood rotate a separation chamber about a rotational axis. The systems and methods introduce whole blood into a first region of the chamber during its rotation to separate the whole blood into a plasma constituent, red blood cells, and an interface between the red blood cells and the plasma constituent. The interface carries mono nuclear cells. While conveying whole blood into the first region, the systems and methods collect the plasma constituent in the first region, while also collecting the red blood cells in a second region of the chamber spaced from the inlet region. The systems and methods create, while conveying whole blood into the inlet region, a back flow of plasma constituent along the interface from the second region toward the inlet region. This back flow of plasma maintains a high-relative hematocrit in the second region and a low-relative hematocrit in the inlet region. The mono nuclear cells are confined between the low-relative hematocrit inlet region and the high-relative second region. The system and method then convey red blood cells into the second region in a back flow direction toward the inlet region. While conveying red blood cells into the second region, the systems and methods collect the mono nuclear cells in the first region.
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Brown Richard I.
Min Kyungyoon
Barrett Joseph B.
Baxter International Inc.
Price Bradford R. L.
Reifsnyder David A.
Ryan Daniel D.
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