Novel 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones

Details Novel 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones Novel 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones

1979-09-27

1981-04-21

Waltz, Thomas A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564433, 564440, 564 83, 564 85, 544 59, 544158, 544236, 544383, 546192, 546334, 26032682, 4242485, 42424852, 424250, 424267, 424263, 424274, 424321, 424330, C07C 8760, C07C 9710, A61K 31135

Patent

active

042634555

ABSTRACT:
The invention relates to novel ortho-aminoacetophenones of the formula I ##STR1## and their tautomers, in which Z is hydrogen, halogen, lower alkyl, cycloalkyl, lower alkoxy, trifluoromethyl, nitro or substituted or unsubstituted sulphamoyl, m is 1 or 2, R is hydrogen, aryl or lower alkyl, R.sub.1 is hydrogen or lower alkyl, R.sub.2 is lower alkyl, cycloalkyl, aryl, cycloalkyl-lower alkyl, aryl-lower alkyl or substituted or unsubstituted pyridyl, R.sub.3 is hydrogen or lower alkyl and n is 1 or 2, with the exception of 2'-[N-(p-methoxyphenyl)-amino]-2-(methyl-sulphinyl)-acetophenone, 2'-amino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-chloro-2-(methylsulphinyl)-acetophenone, 2'-methylamino-2-(methylsulphinyl)-acetophenone, 2'-amino-5'-methyl-2-(methylsulphinyl)-acetophenone, 2'-amino-4'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-6'-chloro-2-(methylsulphinyl)-acetophenone, 2'-amino-5',6'-dimethoxy-2-(methylsulphinyl)-acetophenone and 2'-amino-4',5'-dimethoxy-2-(methylsulphinyl)-acetophenone, and also to their salts.
These compounds have a fibrinolytic and an antiinflammatory action.

REFERENCES:
patent: 2797218 (1957-06-01), Barber et al.
patent: 3355494 (1967-11-01), Lyness et al.
patent: 3409674 (1968-11-01), Moore
patent: 3637803 (1972-01-01), Shen et al.
patent: 3937704 (1976-02-01), Von Strandtmann et al.
patent: 4192873 (1980-03-01), Ferrini et al.
Leonard, "The Chemistry of Cinnolenes," Chim. Rev. 37, pp. 267, 270, 271, 272.

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