Process for the conversion of niddamycin to leucomycin A.sub.1,

Details Process for the conversion of niddamycin to leucomycin A.sub.1, Process for the conversion of niddamycin to leucomycin A.sub.1,

1974-06-03

1976-07-20

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1504

Patent

active

039706427

ABSTRACT:
Covers the process for the conversion of niddamycin to known compounds such as carbomycin B, leucomycin A.sub.1 and A.sub.3, and other antibiotic compounds as well as novel 3-(O)-esters 3-(0)-esters and dimethyl acetal derivatives not obtained from natural sources. These compounds are represented by the general formula: ##SPC1##
Wherein R is hydroxy or oxygen, R.sub.1 is hydrogen, HCO (formyl), CH.sub.3 CO (acetyl), CH.sub.3 CH.sub.2 CO (propionyl) or CH.sub.3 CH.sub.2 CH.sub.2 CO (butyryl); wherein R.sub.2 is hydrogen or equivalent to R.sub.1 and R.sub.3 is CHO or CH(OCH.sub.3).sub.2.
These compounds are useful antimicrobial agents.

REFERENCES:
patent: 3784447 (1974-01-01), Therlault
patent: 3792035 (1974-02-01), Fukatsu et al.
Gaylord, "Reduction w/Complex Metal Hydrides," Interchemical Corp., N.Y., N.Y., 1956, p. 1.
Wagner and Zook, Syn. Org. Chemistry, pp. 261, 262 and 293, Wiley and Sons Inc., New York, 1953.
Gaylord, Reduction with Complex Metal Hydrides, pp. 308, 289 and 290, Interscience Publisher's Ltd., N.Y., N.Y., 1956.

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